MovDisordV3, Main, Exploration, bibRecord, 004406

Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in parkinsonian rats

Identifieur interne : 004406 ( Main/Exploration ); précédent : 004405; suivant : 004407

Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in parkinsonian rats

Auteurs : Marie-Paule Muriel [France] ; Gaël Orieux [France] ; Etienne C. Hirsch [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2002-11.

RBID : ISTEX:20FAF1F51BA9245B355B0F005105096963F26018

Descripteurs français

Pascal (Inist)
- Agoniste, Animal, Antiparkinsonien, Chimiothérapie, Immunohistochimie, Internalisation, Lévodopa, Modèle animal, Parkinson maladie, Rat, Ropinirole, Récepteur dopaminergique D1, Traitement.

English descriptors

KwdEn :
- Agonist, Animal, Animal model, Animals, Antiparkinson Agents (pharmacology), Antiparkinson agent, Carbidopa (pharmacology), Chemotherapy, Corpus Striatum (drug effects), Corpus Striatum (pathology), Cytoplasm (drug effects), Cytoplasm (pathology), D1 Dopamine receptor, D1 dopamine receptor, Drug Combinations, Immunohistochemistry, Indoles (pharmacology), Internalization, Levodopa, Levodopa (pharmacology), Male, Microscopy, Immunoelectron, Neurons (drug effects), Neurons (pathology), Oxidopamine, Parkinson disease, Parkinsonian Disorders (chemically induced), Parkinsonian Disorders (pathology), Rat, Rats, Rats, Sprague-Dawley, Receptors, Dopamine D1 (drug effects), Ropinirole, Synaptic Membranes (drug effects), Synaptic Membranes (pathology), Treatment, Tyrosine 3-Monooxygenase (metabolism), internalization, levodopa, parkinsonian rats, ropinirole.
MESH :
- chemical , drug effects : Receptors, Dopamine D1.
- chemical , metabolism : Tyrosine 3-Monooxygenase.
- chemical , pharmacology : Antiparkinson Agents, Carbidopa, Indoles, Levodopa.
- chemically induced : Parkinsonian Disorders.
- drug effects : Corpus Striatum, Cytoplasm, Neurons, Synaptic Membranes.
- pathology : Corpus Striatum, Cytoplasm, Neurons, Parkinsonian Disorders, Synaptic Membranes.
- Animals, Drug Combinations, Male, Microscopy, Immunoelectron, Oxidopamine, Rats, Rats, Sprague-Dawley.

Abstract

Levodopa therapy in Parkinson's disease is mediated by dopamine receptors and, in a recent study, we showed that a Dl full agonist can induce an internalization of D1 dopamine receptors. The aim of the present study was to determine whether levodopa or a dopamine agonist such as ropinirole can also induce the internalization of D1 dopamine receptors in the striatum of control and hemiparkinsonian rats. The distribution of D1 dopamine receptors was analyzed by immunohistochemistry using a specific antibody. In control animals and 6‐hydroxydopamine (6‐OHDA)‐lesioned animals treated with saline, D1 dopamine receptors were localized at the level of the plasma membrane. In contrast, in both lesioned and nonlesioned animals receiving a single dose of levodopa, but not in animals receiving ropinirole, D1 dopamine receptors were internalized in the cytoplasm. This result is likely explained by the fact that ropinirole binds to non‐D1 dopamine receptors, whereas levodopa, which increases dopamine levels, indirectly acts on both D1 and D2 receptors. Ropinirole is consequently less likely to desensitize D1 dopamine receptors than levodopa and, thus, to reduce the efficacy of the treatment. © 2002 Movement Disorder Society

Url:

https://api.istex.fr/document/20FAF1F51BA9245B355B0F005105096963F26018/fulltext/pdf

DOI: 10.1002/mds.10256

Affiliations:

France
Paris

Le document en format XML

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<front><div type="abstract" xml:lang="en">Levodopa therapy in Parkinson's disease is mediated by dopamine receptors and, in a recent study, we showed that a Dl full agonist can induce an internalization of D1 dopamine receptors. The aim of the present study was to determine whether levodopa or a dopamine agonist such as ropinirole can also induce the internalization of D1 dopamine receptors in the striatum of control and hemiparkinsonian rats. The distribution of D1 dopamine receptors was analyzed by immunohistochemistry using a specific antibody. In control animals and 6‐hydroxydopamine (6‐OHDA)‐lesioned animals treated with saline, D1 dopamine receptors were localized at the level of the plasma membrane. In contrast, in both lesioned and nonlesioned animals receiving a single dose of levodopa, but not in animals receiving ropinirole, D1 dopamine receptors were internalized in the cytoplasm. This result is likely explained by the fact that ropinirole binds to non‐D1 dopamine receptors, whereas levodopa, which increases dopamine levels, indirectly acts on both D1 and D2 receptors. Ropinirole is consequently less likely to desensitize D1 dopamine receptors than levodopa and, thus, to reduce the efficacy of the treatment. © 2002 Movement Disorder Society</div>
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Movement Disorders (revue)

Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in parkinsonian rats

Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in parkinsonian rats

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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